Harmful ecological factors resulted in the fast falling of endocytosis and exocytosis in the cells of liver and blood. What layer of cytolemma is destroying first of all?

Harmful ecological factors resulted in the fast falling of endocytosis and exocytosis in the cells of liver and blood. What layer of cytolemma is destroying first of all?

1.  Lipoproteins


2.  Outer membrane


3.  Bilipid layer


4.  Glycocalyx


5.  *Cortical layer